Figure 1: Open Slide Format and Barcoding Capability Allows  for Multiplexing of up to 256 Samples per run.

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Resequencing experiments are fundamental in basic and clinical research as scientists look for causative mutations within populations. Targeted resequencing involves the comparative analysis of candidate genes or regions and requires a high level of accuracy to identify low frequency SNPs and structural variants.

Traditional capillary electrophoresis methods provide the highest accuracy and are best suited for analyzing a limited set of amplicons in a large number of patient samples.  But this method  becomes expensive and labor intensive when you need to analyze a large number of genes.

SOLiD™ System: Ideal for Large-Scale Resequencing
The SOLiD™ System offers the combination of throughput and accuracy necessary for assaying large numbers of candidate regions or when resequencing pooled or heterogeneous samples. The accuracy, throughput, and versatility of the SOLiD System is uniquely suited for large-scale resequencing experiments.

• The system generates greater than 60 "plus" Gb of mappable data in a single run, providing the coverage and statistical resolving power needed to correctly identify low frequency SNPs in a large number of amplicons.
• The combination of 2 base encoding and dual interrogation of each base results in a system accuracy of greater than 99.94%, and a consensus accuracy at 15x coverage of 99.999%.
• The open slide format and barcoding capability allows for multiplexing of up to 256 samples per run.